This study aims to look closely at the existing disaster response systems in place at King Abdulaziz Hospital (KAH) for national guards :Al-Hassa and to improve the effective management strategic activities of responding when the disaster strikes. The main goals of the study are to determine the demographical information and to assess the knowledge, attitudes and practices towards emergency/disaster preparedness plan . The researcher demonstrated an empirical evidence at KAH to validate that the reliability of the concept that disaster preparedness among the employees wither was applied effectively and efficiently at emergency/disaster situation or not .The sample consists of 210 respondents which have been distributed randomly to KAH's categories. Data were treated statistically by using (online Survey Monkey software program, after that all the responses were downloaded , collected, analyzed ,and graphed into Excel). The researcher applied T-test ,Correlation coefficient and ANOVA test . The result showed that there is a significant relationship between respondent' knowledge / awareness, and attitude towards emergency disaster preparedness practices at KAH' personnel .