Our understanding of the genetics and pathophysiology of animal models for autoimmune diseases such as type 1 diabetes and multiple sclerosis has increased significantly in the past few years. The central themes of this volume are the necessity for novel and improved models, the optimal use of information from animal models to understand pathogenesis of the human disease, and the rational development of novel immunotherapeutics. This volume is intended to foster discussion on the utility of currently available animal models, to suggest methods for improving upon present models, and to advance…mehr
Our understanding of the genetics and pathophysiology of animal models for autoimmune diseases such as type 1 diabetes and multiple sclerosis has increased significantly in the past few years. The central themes of this volume are the necessity for novel and improved models, the optimal use of information from animal models to understand pathogenesis of the human disease, and the rational development of novel immunotherapeutics. This volume is intended to foster discussion on the utility of currently available animal models, to suggest methods for improving upon present models, and to advance translational research in these fields. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Matthias Von Herrath is the editor of How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis?, Volume 1103, published by Wiley. Mark Atkinson is a medical researcher best known for his contributions to research seeking to predict, prevent, and cure type 1 diabetes. He is the author of over 425 publications and is one of the world's most cited diabetes researchers.
Inhaltsangabe
Introduction. Part I: Controversies Surrounding the Use of Animal Models in Type 1 Diabetes and Multiple Sclerosis:. 1. Are Insights Gained from NOD Mice Sufficient to Guide Clinical Translation? Another Inconvenient Truth: Bart O. Roep. 2. Building Different Mouse Models for Human MS: Estelle Bettelli. 3. Autoimmunity and ß Cell Regeneration in Mouse and Human Type 1 Diabetes. The Peace Is Not Enough: Vitaly Ablamunits Nicole A. Sherry Jake A. Kushner and Kevan C. Herold. 4. Diabetes Research in Jeopardy: The Extinction of Clinical Diabetes Researchers: Aldo A. Rossini and Dale L. Greiner. Part II. New Methods of Discovery for Questions of Pathogenesis and Therapy:. In Silico. 5. The Virtual NOD Mouse: Applying Predictive Biosimulation to Research in Type 1 Diabetes: Yanan Zheng Huub T. C. Kreuwel Daniel L. Young Lisl K. M. Shoda Saroja Ramanujan Kapil G. Gadkar Mark A. Atkinson and Chan C. Whiting. 6. Dosing and Timing Effects of Anti-CD40L Therapy: Predictions from a Mathematical Model of Type 1 Diabetes: Kapil G. Gadkar Lisl K. M. Shoda Huub T. C. Kreuwel Saroja Ramanujan Yanan Zheng Chan C. Whiting and Daniel L. Young. Humanized Transgenic or Congenic Models. 7. Autoreactive T Cells in a Partially Humanized Murine Model of T1D: John A. Gebe Ben Falk Kellee Unrath and Gerald T. Nepom. 8. Humanized NOD/LtSz-scid IL2 Receptor Common Gamma Chain Knockout Mice in Diabetes Research: Leonard D. Shultz Todd Pearson Marie King Lisa Giassi Lisa Carney Bruce Gott Bonnie Lyons Aldo A. Rossini and Dale L. Greiner. 9. Development of New-Generation HU-PBMC-NOD/SCID Mice to Study Human Islet Alloreactivity: Marie King Todd Pearson Leonard D. Shultz Jean Leif Rita Bottino Massimo Trucco Mark Atkinson Clive Wasserfall Kevan Herold John P. Mordes Aldo A. Rossini and Dale L. Greiner. 10. Resistance to the Induction of Mixed Chimerism in Spontaneously Diabetic NOD Mice Depends on the CD40/CD154 Pathway and Donor MHC Disparity: Bin Luo Tao Wu Yisheng Pan Hakan Sozen Jianqiang Hao Yu Zhang David E. R. Sutherland Bernhard J. Hering and Zhiguang Guo. 11. "Humanized" HLA Transgenic NOD Mice to Identify Pancreatic ß Cell Autoantigens of Potential Clinical Relevance to Type 1 Diabetes: David V. Serreze Michele P. Marron and Teresa P. Dilorenzo. 12. A New Humanized HLA Transgenic Mouse Model of Multiple Sclerosis Expressing Class II on Mouse CD4 T Cells: Ashutosh Mangalam Moses Rodriguez and Chella David. 13. The Use of Idd Congenic Mice to Identify Checkpoints of Peripheral Tolerance to Islet Antigen: Emma E. Hamilton-Williams Xavier Martinez Michael Lyman Kara Hunter Linda S. Wicker and Linda A. Sherman. 14. Refinement of the Iddm4 Diabetes Susceptibility Locus Reveals TCRVß4 as a Candidate Gene: Elizabeth P. Blankenhorn Cheryl Descipio Lucy Rodemich Laura Cort Jean H. Leif Dale L. Greiner and John P. Mordes. Viral Antigen or Cell-Induced Models. 15. Cytotoxic T Cell-Mediated Diabetes in RIP-CD80 Transgenic Mice: Autoantigen Peptide Sensitivity and Fine Specificity: Klaus Pechhold Sagarika Chakrabarty and David M. Harlan. 16. Coxsackievirus Infections and NOD Mice: Relevant Models of Protection from and Induction of Type 1 Diabetes: Steven Tracy and Kristen M. Drescher. 17. Establishment of a Model to Examine the Early Events Involved in the Development of Virus-Induced Demyelinating Lesions: Kristen M. Drescher and Steven Tracy. 18. Experimental Autoimmune Encephalomyelitis Mediated by CD8+ T Cells: Qingyong Ji and Joan Goverman. 19. Impaired T Cell Receptor Signaling in Foxp3+ CD4 T Cells: Bryan D. Carson and Steven F. Ziegler. 20. Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis: Stephen D. Miller Eileen J. Mcmahon Bettina Schreiner and Samantha L. Bailey. 21. Human Clonal CD8 Autoreactivity to an IGRP Islet Epitope Shared between Mice and Men: W.W.J. Unger G.G.M. Pinkse S. Mulder-Van Der Kracht A.R. Van Der Slik M.G.D. Kester F. Ossendorp J.W. Drijfhout D.V. Serreze and B.O. Roep. Complications. 22. Matrix Metalloproteinase-2 Expression and Apoptogenic Activity in Retinal Pericytes: Implications in Diabetic Retinopathy: Ru Yang Haibo Liu Iyesha Williams and Brahim Chaqour. 23. Mouse Models for Studies of Cardiovascular Complications of Type 1 Diabetes: Xia Shen and Karin E. Bornfeldt. Index of Contributors.
Introduction. Part I: Controversies Surrounding the Use of Animal Models in Type 1 Diabetes and Multiple Sclerosis:. 1. Are Insights Gained from NOD Mice Sufficient to Guide Clinical Translation? Another Inconvenient Truth: Bart O. Roep. 2. Building Different Mouse Models for Human MS: Estelle Bettelli. 3. Autoimmunity and ß Cell Regeneration in Mouse and Human Type 1 Diabetes. The Peace Is Not Enough: Vitaly Ablamunits Nicole A. Sherry Jake A. Kushner and Kevan C. Herold. 4. Diabetes Research in Jeopardy: The Extinction of Clinical Diabetes Researchers: Aldo A. Rossini and Dale L. Greiner. Part II. New Methods of Discovery for Questions of Pathogenesis and Therapy:. In Silico. 5. The Virtual NOD Mouse: Applying Predictive Biosimulation to Research in Type 1 Diabetes: Yanan Zheng Huub T. C. Kreuwel Daniel L. Young Lisl K. M. Shoda Saroja Ramanujan Kapil G. Gadkar Mark A. Atkinson and Chan C. Whiting. 6. Dosing and Timing Effects of Anti-CD40L Therapy: Predictions from a Mathematical Model of Type 1 Diabetes: Kapil G. Gadkar Lisl K. M. Shoda Huub T. C. Kreuwel Saroja Ramanujan Yanan Zheng Chan C. Whiting and Daniel L. Young. Humanized Transgenic or Congenic Models. 7. Autoreactive T Cells in a Partially Humanized Murine Model of T1D: John A. Gebe Ben Falk Kellee Unrath and Gerald T. Nepom. 8. Humanized NOD/LtSz-scid IL2 Receptor Common Gamma Chain Knockout Mice in Diabetes Research: Leonard D. Shultz Todd Pearson Marie King Lisa Giassi Lisa Carney Bruce Gott Bonnie Lyons Aldo A. Rossini and Dale L. Greiner. 9. Development of New-Generation HU-PBMC-NOD/SCID Mice to Study Human Islet Alloreactivity: Marie King Todd Pearson Leonard D. Shultz Jean Leif Rita Bottino Massimo Trucco Mark Atkinson Clive Wasserfall Kevan Herold John P. Mordes Aldo A. Rossini and Dale L. Greiner. 10. Resistance to the Induction of Mixed Chimerism in Spontaneously Diabetic NOD Mice Depends on the CD40/CD154 Pathway and Donor MHC Disparity: Bin Luo Tao Wu Yisheng Pan Hakan Sozen Jianqiang Hao Yu Zhang David E. R. Sutherland Bernhard J. Hering and Zhiguang Guo. 11. "Humanized" HLA Transgenic NOD Mice to Identify Pancreatic ß Cell Autoantigens of Potential Clinical Relevance to Type 1 Diabetes: David V. Serreze Michele P. Marron and Teresa P. Dilorenzo. 12. A New Humanized HLA Transgenic Mouse Model of Multiple Sclerosis Expressing Class II on Mouse CD4 T Cells: Ashutosh Mangalam Moses Rodriguez and Chella David. 13. The Use of Idd Congenic Mice to Identify Checkpoints of Peripheral Tolerance to Islet Antigen: Emma E. Hamilton-Williams Xavier Martinez Michael Lyman Kara Hunter Linda S. Wicker and Linda A. Sherman. 14. Refinement of the Iddm4 Diabetes Susceptibility Locus Reveals TCRVß4 as a Candidate Gene: Elizabeth P. Blankenhorn Cheryl Descipio Lucy Rodemich Laura Cort Jean H. Leif Dale L. Greiner and John P. Mordes. Viral Antigen or Cell-Induced Models. 15. Cytotoxic T Cell-Mediated Diabetes in RIP-CD80 Transgenic Mice: Autoantigen Peptide Sensitivity and Fine Specificity: Klaus Pechhold Sagarika Chakrabarty and David M. Harlan. 16. Coxsackievirus Infections and NOD Mice: Relevant Models of Protection from and Induction of Type 1 Diabetes: Steven Tracy and Kristen M. Drescher. 17. Establishment of a Model to Examine the Early Events Involved in the Development of Virus-Induced Demyelinating Lesions: Kristen M. Drescher and Steven Tracy. 18. Experimental Autoimmune Encephalomyelitis Mediated by CD8+ T Cells: Qingyong Ji and Joan Goverman. 19. Impaired T Cell Receptor Signaling in Foxp3+ CD4 T Cells: Bryan D. Carson and Steven F. Ziegler. 20. Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis: Stephen D. Miller Eileen J. Mcmahon Bettina Schreiner and Samantha L. Bailey. 21. Human Clonal CD8 Autoreactivity to an IGRP Islet Epitope Shared between Mice and Men: W.W.J. Unger G.G.M. Pinkse S. Mulder-Van Der Kracht A.R. Van Der Slik M.G.D. Kester F. Ossendorp J.W. Drijfhout D.V. Serreze and B.O. Roep. Complications. 22. Matrix Metalloproteinase-2 Expression and Apoptogenic Activity in Retinal Pericytes: Implications in Diabetic Retinopathy: Ru Yang Haibo Liu Iyesha Williams and Brahim Chaqour. 23. Mouse Models for Studies of Cardiovascular Complications of Type 1 Diabetes: Xia Shen and Karin E. Bornfeldt. Index of Contributors.
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