This book contains the novel approaches and innovations on how to establish an African Center of Excellence in Clinical and Biomedical Research on Tropical Diseases in collaboration with Institutions and support from donor agencies . The project development plan is fully discussed in this book which includes the Institutional Profile, Objectives of the project, Project Justification, The Development Programme, Work Plan, Human Capacity Building , Training Programmes, Research Linkages, Staff Training and Development as well as the Potential Output/ Achievements Of The Project . This handbook is an indispensable guide for individuals, universities and institutions with plans to establish an African Center of Excellence in Clinical and Biomedical Research on Tropical Diseases in African Countries and other developing countries.