Dropping out of school is a problem that has become an increasingly worrisome reality over time. For this reason, the objective of the research was to identify the factors that influence school dropout among students of the Instituto de Estudios de Bachillerato del Estado de Oaxaca (IEBO) Plantel No. 40 "San Mateo del Mar" Tehuantepec, Oaxaca. The factors that most influence students' decision to drop out of high school are: Personal, Economic, Family and Educational, but the most influential in the IEBO of San Mateo del Mar, is the socioeconomic, where they mention that they would stop studying because they do not have the necessary economic resources. Faced with this problem, the authorities of the state of Oaxaca should pay attention and seek strategies to reduce school dropouts, since this municipality is considered within the national crusade against hunger as one of the municipalities of high and very high marginalization, so it is essential to reduce this situation and thus have a quality education to improve the living conditions of people.