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High Quality Content by WIKIPEDIA articles! Howard Hughes Medical Institute is a United States non-profit medical research institute based in Chevy Chase CDP, Maryland.It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United States. HHMI spends about $1 million per HHMI Investigator per year, which amounts to annual investment in biomedical research of about $450 million. The institute has an endowment of $14 billion, making it the second-wealthiest philanthropic organization in the United States and the second best endowed medical research foundation in the world.HHMI is the former owner of the Hughes Aircraft company - an American aerospace firm which was divested to various firms over time..