Development and validation of RP-HPLC method for the estimation of bulk and pharmaceutical dosage forms within the facilities and therefore the results are incorporated during this thesis. Last a validated RP-HPLC method has been developed for determination of the majority tablet dosage forms. The results show that the tactic was found to be specific, simple, accurate, precise and sensitive. The technique was successfully applied for the determination of the drugs. Several analytical procedures are proposed for the quantitative estimation of separately and together with other drugs. So attempt was taken to develop and validate a reverse phase high performance liquid chromatographic methods for the standard control of in pharmaceutical preparations with lower solvent consumption alongside the short analytical run time that results in an environmentally friendly chromatographic procedure and can allow the analysis of an outsized number of samples during a short period of time. ng a short period of time.