Saurabha Srivastava

HSP70 Protein: Potential Diagnostic Marker For W. bancrofti Infection

Molecular and Epidimological Approaches

• Broschiertes Buch

Produktbeschreibung

Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by Wuchereria bancrofti and Brugia species is one of the most prevalent and yet the most neglected of the tropical diseases with serious economic and social consequences.As asymptomatic microfilaraemic stage is considered as one of the bottlenecks in the global elimination of LF, ScHSP70 can be a promising agent for immunodiagnosis. Also, due to unavailability of W. bancrofti and B. malayi, the bovine filarial parasite, S. cervi can be a good source for heterologous antigens that can be explored as possible candidates for diagnosis, chemotherapy and vaccines. The proteomic analysis is very useful in characterizing ScHSP70 as a disease-associated protein, although proteomics was performed in a small cohort. The results obtained in this study are promising, but further studies on recombinant expression are needed to determine its diagnostic accuracy in the immunodiagnosis of lymphatic filariasis in an endemic area. This study also opens a possibility to explore heat shock proteins for their use in the diagnosis of other helminth diseases too.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 68
• Erscheinungstermin: 10. Juni 2015
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 119g
• ISBN-13: 9783659720895
• ISBN-10: 3659720895
• Artikelnr.: 43189365

Autorenporträt

The author is Doctorate from Banaras Hindu University, India. He has received many National (UGC, CSIR fellow, R.D. Birla) and International (DAAD; German Academic exchange service)awards during his Ph.D. His part of the Ph.D research work was conducted in University of Münster, Germany. Currently he is working as a Project Scientist in CIRBSc.