This book describes the remarkable progress which has been made in defining the extent and nature of human genetic variation. It provides a framework for understanding how research in this area is revolutionising our knowledge of human origins and the genetic basis of disease, as well as common traits such as obesity.
This book describes the remarkable progress which has been made in defining the extent and nature of human genetic variation. It provides a framework for understanding how research in this area is revolutionising our knowledge of human origins and the genetic basis of disease, as well as common traits such as obesity.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Julian Knight gained a BA from the University of Cambridge in 1989, subsequently qualifying in medicine from the University of Edinburgh in 1992. Following junior hospital posts in Edinburgh and Newcastle, he did his DPhil at the Weatherall Institute of Molecular Medicine in Oxford. In 1999 he began post-doctoral research as an MRC Clinician Scientist in Oxford and Harvard. He has been a Wellcome Trust Senior Research Fellow in Clinical Science at the Wellcome Trust Centre for Human Genetics in Oxford since 2005 and is an honorary Consultant in Internal Medicine at the John Radcliffe Hospital. He was elected fellow of the Royal College of Physicians in 2007 and was awarded the Linacre Medal by the Royal College of Physicians in 2008. His current research programme investigates the functional consequences of genetic variation for genetic variation for gene regulation with a particular interest in immune and infectious disease.
Inhaltsangabe
* 1: Lessons From Haemoglobin * 2: Finding Genes and Specific Genetic Variants Responsible for Disease * 3: Cytogenetics and Large Scale Structural Genomic Variation * 4: Submicroscopic Structural Variation in Health and Susceptibility to Disease * 5: Submicroscopic Structural Variation and Genomic Disorders * 6: Segmental Duplications and Indel Polymorphisms * 7: Tandem Repeats * 8: Mobile DNA Elements * 9: SNPs, HapMap and Common Disease * 10: Fine Scale Sequence Diversity and Signatures of Selection * 11: Genetics of Gene Expression * 12: Extreme Diversity in the Major Histocompatibility Complex * 13: Parasite Wars * 14: Human Genetic Diversity and HIV: Lessons From a War Fought on Many Fronts * 15: Concluding Remarks and Future Directions * Glossary * References * Index
* 1: Lessons From Haemoglobin * 2: Finding Genes and Specific Genetic Variants Responsible for Disease * 3: Cytogenetics and Large Scale Structural Genomic Variation * 4: Submicroscopic Structural Variation in Health and Susceptibility to Disease * 5: Submicroscopic Structural Variation and Genomic Disorders * 6: Segmental Duplications and Indel Polymorphisms * 7: Tandem Repeats * 8: Mobile DNA Elements * 9: SNPs, HapMap and Common Disease * 10: Fine Scale Sequence Diversity and Signatures of Selection * 11: Genetics of Gene Expression * 12: Extreme Diversity in the Major Histocompatibility Complex * 13: Parasite Wars * 14: Human Genetic Diversity and HIV: Lessons From a War Fought on Many Fronts * 15: Concluding Remarks and Future Directions * Glossary * References * Index
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