Trophoblasts are cells in the human placenta that play a vital role in fetal growth and pregnancy. This book discusses the role of nutrients on human placental development with particular focus on the impact of nutrients on trophoblast function. Exposure to nutrients in utero is critical, as it affects the development of chronic diseases such as type2 diabetes, cardiovascular diseases, hypertension and obesity in later life. The text also reviews the role of fatty acids, folic acids and specific vitamins.
Trophoblasts are cells in the human placenta that play a vital role in fetal growth and pregnancy. This book discusses the role of nutrients on human placental development with particular focus on the impact of nutrients on trophoblast function. Exposure to nutrients in utero is critical, as it affects the development of chronic diseases such as type2 diabetes, cardiovascular diseases, hypertension and obesity in later life. The text also reviews the role of fatty acids, folic acids and specific vitamins.
Dr. Asim K. Duttaroy was educated in India and USA. Currently he is the Professor and group leader, Chronic disease, Dept. of Nutrition, Faculty of Medicine at the University of Oslo, Norway. After his fellowship at the Thrombosis Research Centre, Temple University Medical School, he joined as an Assistant Professor of Medicine and Biochemistry at the Wright State University, and Senior Health Scientist at the VA Medical Centre, Dayton, Ohio. He then moved to the Rowett Research Institute of Aberdeen University, Scotland, UK as the Professor and the Principal Scientist. In 2001, he was appointed as Professor and Group leader at the University of Oslo, Norway. His research program focuses on the roles of dietary components on growth, development, as well as in the prevention of cardiovascular disease. He is investigating the mechanisms responsible for cellular growth, function and metabolism of dietary lipids in feto-placental unit. He holds several international patents. His discovery Fruitflow(TM) is scientifically-proven to inhibit platelet aggregation, a known cause of heart attack, stroke and venous thrombosis. It became the first product in Europe to obtain an approved positive health claim under the European Food Safety Authority (EFSA) regulations. Prof. Duttaroy is a member of several International societies and editorial board of several international journals. Recently he was appointed as the Editor-In-Chief of Food & Nutrition Research journal. His scientific work has been published in over 175 original contributions, reviews , book, book chapters, and editorials. He has supervised 25 PhD/MD students so far. He has personal website http://www.asimduttaroy.com where his activities are regularly updated. Dr. Sanjay Basak is a Researcher. At present he is working as a Scientist at the Division of Molecular Biology, National Institute of Nutrition (ICMR), India. After receiving his PhD in Biochemistry, he joined as a Research Officer to this institute. Recently he completed his research training fellowship in Nutrition, Physiology and Molecular Biology from the Institute of Basic Medical Sciences, University of Oslo, Norway. His research is actively involved in molecular aspects of nutrition, trophoblast growth, development and placentation. He secured a competitive overseas research fellowship grant (BOYSCAST) from Govt. of India. He was a recipient of Henrik Homans Memorial Scholarship, Norway. Currently, he is associated as an Editorial Member of the peer-reviewed international journal "Food and Nutrition Research", Co-action Publisher, Sweden. Till date, he has published 16 research articles, 2 review papers and one book chapter. Most of his work is available at https://scholar.google.com/citations?user=Sxz3LsMAAAAJ&hl=en
Inhaltsangabe
Preface. Overview of the Book. Organization of Human Placenta and Structure and Function of Trophoblast. Introduction to the Key Nutrients and Their Implication on Placentation. Amino Acid Transport and Metabolism of the Trophoblast Cells. Transport and Metabolism of Lipids in Trophoblast Cells. Maternal Lipid and Their Impact on Angiogenesis and Invasion of Trophoblast. Folic Acid, Vitamin B12, Vitamin D on Cellular Growth, Angiogenesis and Invasion of Trophoblast. Nuclear Transcription Factors and Their Effect on Trophoblast Metabolism. Effect of Adipokines on Angiogenesis and Invasion of the Trophoblast Cells. Hyperglycemia and Hypoxia on Angiogenesis and Invasion of the Trophoblast Cells. Regulation of Gene Expression During Angiogenesis and Invasion of the Trophoblast. Index.
Preface. Overview of the Book. Organization of Human Placenta and Structure and Function of Trophoblast. Introduction to the Key Nutrients and Their Implication on Placentation. Amino Acid Transport and Metabolism of the Trophoblast Cells. Transport and Metabolism of Lipids in Trophoblast Cells. Maternal Lipid and Their Impact on Angiogenesis and Invasion of Trophoblast. Folic Acid, Vitamin B12, Vitamin D on Cellular Growth, Angiogenesis and Invasion of Trophoblast. Nuclear Transcription Factors and Their Effect on Trophoblast Metabolism. Effect of Adipokines on Angiogenesis and Invasion of the Trophoblast Cells. Hyperglycemia and Hypoxia on Angiogenesis and Invasion of the Trophoblast Cells. Regulation of Gene Expression During Angiogenesis and Invasion of the Trophoblast. Index.
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