The study evaluated human resources management practices (HRMPs) impact on Small to Medium Enterprises (SMEs) performance in Harare and Mashonaland West Provinces in Zimbabwe. Many countries of the world today rely on a vibrant SMEs sector. From global perspectives SMEs sector is viewed as the fulcrum for the general development of the economy leading the countries to meet some of their objectives of unemployment reduction, poverty reduction, economic growth and development. The SMEs are regarded as the veritable vehicles. The study was prompted by failures of SMEs. In this study five hundred respondents were used as research subjects from SMEs in manufacturing, service provision, retailing and wholesaling. The study adopted mixed method approach rooted in the pragmatism paradigm. This study used a cross sectional descriptive survey research design and the sample was randomly selected from the population. Probability and non probability sampling method was used in this study to ensure that the sample being studied was representative of the population of interest. Interviews and questionnaires were data collection instruments used in this study.