Huntington - Fymat, Alain L
165,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 1-2 Wochen
payback
83 °P sammeln
  • Broschiertes Buch

Huntington's disease is a rare inherited, progressive, incurable, and fatal neurodegenerative disorder of the central nervous system. It affects muscle function and further leads to cognitive decline and dementia. It can present at any time in people during their life span. Symptoms may vary from person to person and usually appear in people who are in their 30s or 40s, but also earlier in life and even in children younger than 10. Most symptoms can be classified under motor, behavioral, or cognitive categories. The disease is caused by a defective gene characterized by an excessive number of…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
Huntington's disease is a rare inherited, progressive, incurable, and fatal neurodegenerative disorder of the central nervous system. It affects muscle function and further leads to cognitive decline and dementia. It can present at any time in people during their life span. Symptoms may vary from person to person and usually appear in people who are in their 30s or 40s, but also earlier in life and even in children younger than 10. Most symptoms can be classified under motor, behavioral, or cognitive categories. The disease is caused by a defective gene characterized by an excessive number of trinucleotide (Cystosine-Adenine-Guanine) repeats - a part of the DNA code. The gene produces a protein of unknown function named Huntingtin, which is involved in the functioning of the nerve cells in the brain (neurons). When defective, the gene produces an abnormal (or mutated) Huntingtin protein that is toxic and causes selective loss of neurons. The pathogenesis of the disease remains, however, largely unclear so that the exact cause of neuronal death is unknown. Since each patient may have a unique combination of symptoms, there is no standardized treatment so that medication is prescribed on a case-by-case basis. Pharmacotherapy includes chorea medication, antipsychotics, antidepressants, mood-stabilizing medication as well as non-drug therapies. Side effects from medications can also affect each patient differently. Notwithstanding such approved therapies for specific disease symptoms, there is currently no cure and there are no approved drugs that delay the onset or slow disease progression. Fortunately, there are also many new therapeutics currently undergoing clinical trials that target the disease at its origin by lowering the levels of the mutant Huntingtin protein. In this book, I discuss the disease at length in its multiple facets and address the issue of its prevention and prognosis. I also consider what can be done about it and list the several available support and research organizations. Lastly, I review the current research and latest research developments in this subject.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Autorenporträt
DR. ALAIN L. FYMAT is the Founding Chair, current President/CEO, and Institute Professor at the International Institute of Medicine & Science with a previous appointment as Executive Vice President, Chief Operating Officer, and Professor at the Weil Institute of Critical Care Medicine, both Institutes in California, U.S.A. He was formerly Professor of Radiology, Radiological Sciences, Radiation Oncology, Critical Care Medicine, and Physics at several U.S. and European Universities. Earlier, he was Deputy Director (Western Region) of the U.S. Department of Veterans' Affairs, Veterans' Health Administration (Office of Research Oversight). At the Loma Linda Veterans' Affairs Medical Center, he was Scientific Director of the Radiology Service, Director of the Magnetic Resonance Imaging Center and, for a time, Acting Chair of Radiology. Previously, he was also Director of the Division of Biomedical & Biobehavioral Research at the University of California at Los Angeles/Drew University of Medicine & Science. He was also Scientific Advisor to the U.S. National Academy of Sciences, National Research Council, for its postdoctoral programs tenable at the California Institute of Technology and member of the Advisory Board for Research & Development, North Atlantic Treaty Organization (NATO), Advisory Group for Research & Development (AGARD). He is Health Advisor to the American Heart & Stroke Association, Coachella Valley Division, California. He is a member of the New York Academy of Sciences and the European Union Academy of Sciences, and a reviewer for the prestigious UNESCO Newton Prize, United Kingdom. Dr. Fymat's current research interests are currently focused on neurodegenerative diseases, including Huntington's disease among several others.