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Despite many studies investigating Hurthle cell lesions (HCLs) in general and Hurthle cell neoplasms (HCNs) in particular, only a few facts are established while uncertainties still obscure much of the disease spectrum. This book explores and discusses the controversies and debates related to Hurthle cell lesions of the thyroid gland including nomenclature, diagnosis, pathology, clinical behavior, management, and prognosis.