V. N. Khabarov, P. Y. Boykov, M. A. Selyanin

Gebundenes Buch

Hyaluronic Acid

Production, Properties, Application in Biology and Medicine

Herausgegeben von Polyak, Felix

Beschreibung

Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process.

Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to the practical applications of hyaluronan.Chapter 2 is dedicated to biological role of the hyaluronic acid innature, in particular in the human body. The chapter starts fromthe phylogenesis of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially the role whichhyaluronan plays in extracellular matrix of the different tissues.Chapter 3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical means for assessingquality of the finished product. Chapter 4 discusses the structureand rheological properties of hyaluronic acid considering effectson conformation and biological properties related to molecularweight. In Chapter 5, the physical and chemical methods formodifying the structure of hyaluronan are discussed includingcross-linking using bi-functional reagents, solid-phasemodification and effects of the combined action of high pressuresand shift deformation. The final chapter focuses on the productsderived from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated to vitamins, amino acids andoligo-peptides. The biological roles and medical applications ofthis polysaccharide have been extensively studied and this bookprovides a wealth of scientific data demonstrating the criticalrole of hyaluronic acid and its promise as a multifacetedbio-macromolecule.

Approaching hyaluronic acid from multiple angles, this booklinks relationships between its biological functions, structure andphysical-chemical properties. It will be an invaluableresource to researchers, both industrial and academic, involved inall aspects of hyaluronan-based technologies.

Autor

Dr Vladimir N. Khabarov is Scientific Director at Group Martinex He has comprehensive academic knowlege and expeience in radiochemistry, chemistry of polymers, bioorganic chemistry. Experience in research and development of medicinal products. He has extensive publication experience with 90 scientific papers and 10 patents. Dr Petr Ya. Boikov worked at the I.M.Sechenov Moscow Medicinal Academy as Professor of cell biology, before moving to Group Martinex. He has a PhD in biologcy and works in organic, medicinal and biochemistry, molecular and cell biology, focusing on research of the mechanisms of the biologic and medicinal action of the new chemical products. Dr Mikhail A. Selyanin is a specialist in dermatology and aesthetic medicine and works as part of LLC GC Martinex a major supplier of aesthetic medicine products and equipment in Russia and Eastern Europe. Toskani Laboratory, a subsidiary of Martinex Group produces injection drugs fillers and chemical peels, with their research centre working on new applications of our patented solid-state modification technique of hyaluronic acid. He was vice-president of Institute of microcells at UNESCO, León, 2012 and President of National Society of Mesotherapy in 2008. Dr Felix Polyak is Chief Operating Office at Aluron Biopharma Inc in Montreal Canada. He received his PhD in Organic Chemistry at the Institute of Organic Synthesis, Riga, Latvia, in the early 1970s. He has academic and inductrial experience in organic, medicinal and peptide chemistry. Experience in all chemical aspects of drug development, such as R&D, scale-up and process development, GMP manufacturing and drug product formulation. He is a member of the Chemical Institute of Canada, the European Peptide Society and the American Peptide Society. He has published more than 40 scientific papers and 7 patents.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 224
• Erscheinungstermin: 27. Februar 2015
• Englisch
• Abmessung: 244mm x 170mm x 15mm
• Gewicht: 544g
• ISBN-13: 9781118633793
• ISBN-10: 1118633792
• Artikelnr.: 41628825