At the present stage of development of society, in the conditions of scientific and technological progress, the flow of incoming information is continuously increasing. The assimilation of this information and the fruitful development of new ideas requires a significant intensification of human mental activity. The need for highly qualified specialists is increasing.When analyzing the literature, special attention was paid to publications containing information about the hygienic conditions of knowledge workers, because Medical workers are prominent representatives of this category of work. We also analyzed those literary sources that include material on the influence of various factors on physiological changes in the body, the intensity of the labor process and the development of fatigue during work.