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Today greater than usual emphasis is required on experimental models of translational studies to better understand the developmental origins of cardiovascular and metabolic disease process. This animal based work presented here demonstrates that long-term maternal high fat feeding from weaning through pregnancy and lactation predisposes offspring to cardiovascular disease and metabolic syndrome. Early pharmacological treatment of these dams inhibits these effects on the offspring and reduce their risk of later cardiovascular pathophysiology. These findings may have important implications on…mehr

Produktbeschreibung
Today greater than usual emphasis is required on experimental models of translational studies to better understand the developmental origins of cardiovascular and metabolic disease process. This animal based work presented here demonstrates that long-term maternal high fat feeding from weaning through pregnancy and lactation predisposes offspring to cardiovascular disease and metabolic syndrome. Early pharmacological treatment of these dams inhibits these effects on the offspring and reduce their risk of later cardiovascular pathophysiology. These findings may have important implications on elucidating the underlying mechanisms of increased prevalence of cardiovascular disease and metabolic syndrome in many societies.
Autorenporträt
The 1st author (Maqsood Elahi) is an adult & paediatric cardiothoracic surgeon and the 2nd author (Bashir Matata) is a Fellow of the Royal Society (Med) acclaimed scientist. Both enjoy a track record of achievements in academia and health service with main area of research on Free Radicals and Oxidative Stress in Cardiovascular Disease.