Luis de Lecea / J. Gregor Sutcliffe (eds.)

Hypocretins

Integrators of Physiological Signals
Ed. by L. de Lecea and J. G. Sutcliffe

• Gebundenes Buch

Produktbeschreibung

The hypocretins (orexins) are a newly identified (1998) peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides, located primarily in the hypothalmus, in the regulation of behavioral state. They are involved in circadian rhythms, metabolism, hormone secretion, body temperature, appetite, cardiovascular functions (e.g., blood pressure), and sleep abnormalities (e.g., narcolepsy and cataplexy).

Produktdetails

• Verlag: Springer, Berlin
• 2005
• Seitenzahl: 468
• Erscheinungstermin: 29. September 2005
• Englisch
• Abmessung: 241mm x 160mm x 34mm
• Gewicht: 1136g
• ISBN-13: 9780387250007
• ISBN-10: 038725000X
• Artikelnr.: 14844353

Autorenporträt

Luis de Lecea, The Scripps Research Institute La Jolla, CA, USA / J. Gregor Sutcliffe, The Scripps Research Institute La Jolla, CA, USA

Inhaltsangabe

Foreword.- Preface.- The Discovery of The Hypocretins.- Orexin and Orexin Receptors.- Rodent Models of Human Narcolepsy-Cataplexy.- The Canine Model of Narcolepsy.- Anatomy of The Hypocretin System.- The Anatomy of Hypocretin Neurons.- Transmitter-Identified Neurons and Afferent Innervation of The Lateral Hypothalamic Area.- Physiological Characteristics of Hypocretin/Orexin Neurons.- The Ne System as A Target For Hypocretin Neurons: Implications For Regulation of Arousal.- Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State.- The Aminergic Systems and The Hypocretins.- Effects of Hypocretin/Orexin on The Thalamocortical Activating.- In Vivo Pharmacology of Orexin (Hypocretin) Receptors.- Intracellular Signal Pathways Utilized by The Hypocretin/Orexin Receptors.- The Hypocretins and Narcolepsy.- An Approach to Determining The Functions Of Hypocretin (Orexin).- Hypocretin In Neuropsychiatric Disorders.- Hypocretin/Orexin And Sleep.- Modulation Of Cortical Activity And Sleep-Wake States By Hypocretin/Orexin.- Regulation Of Hypocretin By Metabolic Signals.- Hypocretin And Brain Reward Function.- Orexin/Hypocretin And Opioid Dependence.- Dopamine.- Hypocretin/Orexin Interactions.- Hypocretin/Orexin In Stress And Arousal.- The Hypocretins/Orexins And The Hypothalamo-Pituitary-Adrenal Axis.- Orexins (Hypocretins) In The Gut.- Hypocretins In Endocrine Regulation.- The Hypocretins In Cardiovascular Regulation.- Index.