Hypoglycemic and hypolipidemic effects of khellin: Experimental study - AbouSamra, Mona;Basha, Mona;ElAwdan, Sally
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The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-beta-cyclodextrin (MbetaCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects. This study points for the first time that the complexation of Khellin with Methyl-betaCyclodextrin could notably improve the dissolution rate and hence the bioavailability of khellin. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment for type 2 diabetes mellitus (T2DM).

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Produktbeschreibung
The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-beta-cyclodextrin (MbetaCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects. This study points for the first time that the complexation of Khellin with Methyl-betaCyclodextrin could notably improve the dissolution rate and hence the bioavailability of khellin. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment for type 2 diabetes mellitus (T2DM).
Autorenporträt
Dr. Mona AbouSamra hat mehrere Veröffentlichungen auf dem Gebiet der pharmazeutischen Technologie im Zusammenhang mit Arzneimittelabgabesystemen veröffentlicht. Ihre Forschungen konzentrieren sich hauptsächlich auf die Verbesserung der Medikamentenfunktion und die Suche nach einfachen und kostengünstigen Methoden zur Steigerung der Medikamenteneffizienz.