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Flaxseed and garlic have a number of potential health benefits, including antioxidant properties and they can lower the cholesterol in the blood, which could prevent hyperlipidemia. In this study, the hypolipidemic effect of flaxseed and garlic was investigated. Interview schedule was used to collect information regarding socio economic status, dietary and exercise pattern, anthropometric measurements and biochemical estimation and history and duration of disease for a sample of 100 hypercholesterolemic people including males and female subjects free from serious complications aged 30-60 years, among them 10 were in the experimental group supplemented with flaxseed and garlic mix for a period of 45 days and 10 acts as control subjects without any supplementation. The mean total and LDL cholesterol level of experimental group before the supplementation was 218.6 mg/dl and 142.9 mg/dl had reduced to 191.9 mg/dl and 114.3 mg/dl respectively after the supplementation period of 45 days. The difference showing statistical significance at p(0.01) level. From the results obtained for the lipid profile, it was concluded that, supplementation of flaxseed and garlic as a mix is highly help