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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Integrated discrete Multiple Organ Culture (IdMOC) is an in vitro, cell culture based experimental model for the study of intercellular communication. In conventional in vitro systems, each cell type is studied in isolation ignoring critical interactions between organs or cell types. IdMOC technology is based on the concept that multiple organs signal or communicate via the systemic circulation (i.e., blood).The IdMOC plate consists of multiple inner wells within a…mehr

Produktbeschreibung
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Integrated discrete Multiple Organ Culture (IdMOC) is an in vitro, cell culture based experimental model for the study of intercellular communication. In conventional in vitro systems, each cell type is studied in isolation ignoring critical interactions between organs or cell types. IdMOC technology is based on the concept that multiple organs signal or communicate via the systemic circulation (i.e., blood).The IdMOC plate consists of multiple inner wells within a large interconnecting chamber. Multiple cell types are first individually seeded in the inner wells and when required are flooded with an overlying medium to facilitate well-to-well communication. Test material can be added to the overlying medium and both media and cells can be analyzed individually. Plating of hepatocytes with other organ-specific cells allows evaluation of drug metabolism and organotoxicity.