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This text explains complex, theory-laden topics in image processing through examples and MATLAB® algorithms. It provides these algorithms to help scientists and researchers quickly identify the most effective solution method for a particular problem at hand. The authors emphasize three-dimensional processing and analysis as well as statistical and stochastic modeling. They cover the new areas of nonlinear diffusion filtering and PDE-based image filtering, address relatively advanced topics, such as Markov random field-based image segmentation, and highlight applications with images from medicine and biology. They also include real-world examples and exercises in every chapter.