Imaging PET Reporter Transgenes in Living Subjects
Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes
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Non-invasive imaging of transgene expression shouldsoon play a critical role in gene and adoptivecellular gene therapy clinical trials. Positronemission tomography (PET) reporter genes (PRG)/probes(PRP) are currently the most advanced technologiesavailable for imaging transgens in humans. PRGs canbe used to image the location, magnitude, and timevariation of the intensity of transgene expressionthroughout the whole body of a patient. This caneliminate the need for multiple biopsies, which arepotentially dangerous and yet do not provide acomplete picture of whole body transgene expressionat mul...
Non-invasive imaging of transgene expression should
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene expression
at multiple time points. This dissertation provides
details of several studies on direct and indirect
imaging of therapeutic transgenes using multiple
PRG/PRP systems in mice. Furthermore, it includes the
details of the first study on the pharmacokinetics,
dosimetry, and safety of an imaging reporter probe in
humans. Finally, a complete background on alternate
methods of imaging transgene expression has been
provided, concluding with a discussion of potential
future applications of imaging in gene therapy.
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene expression
at multiple time points. This dissertation provides
details of several studies on direct and indirect
imaging of therapeutic transgenes using multiple
PRG/PRP systems in mice. Furthermore, it includes the
details of the first study on the pharmacokinetics,
dosimetry, and safety of an imaging reporter probe in
humans. Finally, a complete background on alternate
methods of imaging transgene expression has been
provided, concluding with a discussion of potential
future applications of imaging in gene therapy.
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