Shahriar Yaghoubi

Imaging PET Reporter Transgenes in Living Subjects

Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes

• Broschiertes Buch

Produktbeschreibung

Non-invasive imaging of transgene expression should
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene expression
at multiple time points. This dissertation provides
details of several studies on direct and indirect
imaging of therapeutic transgenes using multiple
PRG/PRP systems in mice. Furthermore, it includes the
details of the first study on the pharmacokinetics,
dosimetry, and safety of an imaging reporter probe in
humans. Finally, a complete background on alternate
methods of imaging transgene expression has been
provided, concluding with a discussion of potential
future applications of imaging in gene therapy.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 216
• Englisch
• Gewicht: 300g
• ISBN-13: 9783639115178
• ISBN-10: 3639115171
• Artikelnr.: 26052541

Autorenporträt

Dr. Yaghoubi is currently a research scientist at the department
of Radiology, Molecular Imaging Program at Stanford University.
He received his Bachelors in Science in Biomedical Engineering
from University of Southern California in 1996 and his Ph.D. in
Molecular and Medical Pharmacology from University of California,
Los Angeles in 2002.