HIV/AIDS has challenged humans perhaps more than any other pandemic in recent history. In the era of globalization and increased movement of people crossing borders, immigrants especially from HIV prone countries to the western world have been singled out as one of the risk groups by host nations.In countries like Sweden, where multicultural society is in the making, HIV prevention programs have targeted immigrants more than others. However, HIV infections are still on the increase and HIV prevention strategies and methods have been questioned. This book explores the views of HIV prevention workers drawn from immigrants themselves and closely examines explanations from structural to specific contextual factors for the challenges of HIV prevention in multicultural neighborhoods of Gothenburg city in Sweden. The study surfaces out new dimensions that have not been sufficiently addressed by concerned bodies in HIV prevention efforts. The analysis from this study would help policy makers, professionals, HIV practitioners and ordinary people especially in the western world, where immigrants are significant proportion of society.