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This issue covers important topics to any primary care physician such as: Immunology for the primary care physician, Routine pediatric immunization, special cases in pediatrics, Routine adult immunization, special cases in adult vaccination, Foreign born individuals, Travel medicine, Immunoglobulins, Pandemic illness/flu , Future vaccine development, clinical trials, immunization and cancer prevention/treatment, Ethics of vaccination refusal, Vaccine administration: Rules and regulations, and Keeping current with vaccine recommendations