Andere Kunden interessierten sich auch für
![Effects of Tualang Honey on Non-Alcoholic Steatohepatitis Rat Model]( "Effects of Tualang Honey on Non-Alcoholic Steatohepatitis Rat Model")
Effects of Tualang Honey on Non-Alcoholic Steatohepatitis Rat Model24,99 €![RADIOSENSITIZING GLIOBLASTOMA IN A RAT MODEL]( "RADIOSENSITIZING GLIOBLASTOMA IN A RAT MODEL")
RADIOSENSITIZING GLIOBLASTOMA IN A RAT MODEL32,99 €![Hemangiopericytoma of the greater omentum]( "Hemangiopericytoma of the greater omentum")
Hemangiopericytoma of the greater omentum23,99 €![Aging changes in the retina]( "Aging changes in the retina")
Aging changes in the retina29,99 €![Physiological Immunohistochemical Changes in Prostate Cancer Patients]( "Physiological Immunohistochemical Changes in Prostate Cancer Patients")
Physiological Immunohistochemical Changes in Prostate Cancer Patients51,99 €![Dietary Assessment and Recommendation Model for Indian Elderly Persons]( "Dietary Assessment and Recommendation Model for Indian Elderly Persons")
Dietary Assessment and Recommendation Model for Indian Elderly Persons44,99 €![Different Roles of Immunohistochemical Markers in Cancer]( "Different Roles of Immunohistochemical Markers in Cancer")
Different Roles of Immunohistochemical Markers in Cancer23,99 €
In this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (OBNSC/NPCs) transplanted into the rat hippocampus treated with ibotenic acid (IBO). We assessed their possible ability to survive, integrate, proliferate, and differentiate into different neuronal and glial elements: we also evaluate their possible therapeutic potential following their engraftment into the CNS milieu. OBNSC/NPCs were isolated from adult human olfactory bulb patients, genetically engineered to express GFP and human nerve growth factor (hNGF) by lentivirus-mediated infection, and stereotaxically transplanted into the hippocampus of IBO-treated animals. Stereological analysis of engrafted OBNSCs eight weeks post transplantation revealed a 1.89 fold increase with respect to the initial cell population, indicating a marked ability for survival and proliferation. This work demonstrated that human OBNSCs-NGF ameliorate the cognitive deficiencies associatedwith IBO-induced lesions in AD model rats, and the improvement can probably be attributed primarily to neuronal and glial cell replacement as well as the trophic influence exerted by the secreted NGF.