Immunologic Signatures of Rejection

Herausgegeben:Marincola, Francesco M.; Wang, Ena

• Gebundenes Buch

Produktbeschreibung

This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 12712267, 978-1-4419-7218-7
• 2011
• Seitenzahl: 364
• Erscheinungstermin: 3. November 2010
• Englisch
• Abmessung: 241mm x 160mm x 26mm
• Gewicht: 656g
• ISBN-13: 9781441972187
• ISBN-10: 1441972188
• Artikelnr.: 30537119

Inhaltsangabe

Part One
From "delayed allergy reaction" to the "immunologic constant or rejection" 1. Ena Wang and Francesco M Marincola Part Two
The immune biology of rejection; basic principles 2. Experimental models of rejection
Anil Shanker A 3. Cancer and Inflammation
Alberto Mantovani 4. The immunologic switch
Giorgio Trinchieri 5. The angiogenic switch
Douglas Noonan 6. Chemokines and cytotoxic effector molecules in rejection
Alan Krensky 7. Immune cell activation: the clinical perspective
David F Stroncek Part Three
Circulating patterns associated with chronic and acute immune pathology 8. Immune signatures detectable in peripheral lymphocytes: a modular view
Damien Chaussabel 9. Immune signatures associated with unresolving compared to resolving infections: the HCV model
Robert E Lanford 10. Immune signatures associated with unresolving infections: the HIV model
Luigi Buonaguro 11. Immune signatures associated with the cancer
bearing status
Peter P Lee Part Four
Tissue
specific patterns associated with chronic inflammatory processes 12. Signatures associated with destructive autoimmune pathologies
Steve Jacobson 13. Predictors of favorable outcome in cancer
Zoltan Pos 14. Other predictors of outcome
George Coukos 15. Transcriptional profiling of melanoma as a potential predictive biomarker for response to immunotherapy
Thomas F. Gajewski 16. Predictors of allograft rejection
Sarwal Minnie Part Five
Signatures associated with acute rejection 17. Graft vs Host
Fran Hakim 18. Tumor rejection
Ena Wang 19. Allograft rejection
Davide Bedognetti