Throughout the centuries natural compounds have been widely used for the prevention and treatment of different diseases. One of the groups of natural compounds that has recently attracted increased interest of researchers and clinicians are fungal polysaccharides. Along with the macroscopic fungi, or mushrooms, yeasts also represent a source of valuable polysaccharides contained in their cell walls. Beta glucan as part of yeasts cell wall were highly concentrated on their biological activity and their interaction as non-adaptive immunomodulating agent and other biological effects when applied in different systems in vivo and in vitro. For this reason this study aimed to investigate the effect of beta-glucan as anti-angiogenic agent and other immunological effect.