In this book reviewed the immunomodulation of plant extracts in laboratory animals and in cell culture. This problem can be at the on the border of different scientific disciplines and therefore still developing in a fragmented way. Traditionally provided extracts of the plant injected with antigen induce humoral and cellular immunity. Moreover, studies have been conducted using plants as endemics so from the flora of different habitats. In plant extracts immunomodulatory properties of cyclic and heterocyclic organic compounds. In addition, the positive role of trace elements in the induction of immune response in part well known. Currently, continues active analysis of minerals in plants and found, so-called hubs of certain trace elements. The author first proposed a formula for calculating the energy impact of chemical elements in vivo and in vitro. It was received a number of trace elements the degree of impact. The specified formula is derived based on the concentration of trace elements which used in the immunization of laboratory animals. This account will allow to improve the selection of trace elements in the composition of vaccines and drugs to maintain an active life.