The aims of the book are to provide an authoritative reference for academic and clinical research scientists and teachers with interests in immunology, inflammation and pharmacology and we are grateful to all the contributors who have presented the most up-to-date information available. We believe that the book will stimulate the concept of immunopharmacology as a true discipline if pharmacology with exciting avenues to be rapidly explored and which should lead to the alleviation of the destructive inflammatory arthritides.
The aims of the book are to provide an authoritative reference for academic and clinical research scientists and teachers with interests in immunology, inflammation and pharmacology and we are grateful to all the contributors who have presented the most up-to-date information available. We believe that the book will stimulate the concept of immunopharmacology as a true discipline if pharmacology with exciting avenues to be rapidly explored and which should lead to the alleviation of the destructive inflammatory arthritides.
Contributors. Series Preface. Preface. Introduction. The Background to Autoimmunity, W.M. Williams, M.R. Ehrenstein, and D.A. Isenberg. Immunological Tolerance and its Implications for Autoimmunity, N.A. Mitchison. Peptide Blockade and Antigen-specific Modulation of Autoimmune Disease, D.C. Wraith. Monoclonal Antibody Therapy of Experimental Arthritis - Comparison with Cyclosparin A for Elucidating Cellular and Molecular Disease Mechanisms, M.E.J. Billingham. Anti-CD4 and Other Antibodies to Cell Surface Antigens for Therapy, F. Emmrich, H. Schulze-Koops, and G. Burmester. Are Imbalances in Cytokine Function of Importance in the Pathogenesis of Rheumatoid Arthritis?, M. Feldmann, F.M. Brennan, E.R. Abney, A. Hales, Y. Chernajovsky, P. Katsikis, A. Corcoran, C. Haworth, A. Cope, D. Gibbons, C.Q. Chu, M. Field, B. Deleuran, R.O. Williams, and R.N. Maini. Naturally Occuring Inhibitors of Cytokines, W.P. Arend and J.-M. Dayer. Soluble Immunopeptides in Inflammatory Arthritis, J.A. Symons and G.W. Duff . Inflammatory Reactions in Arthritis, H.-G. Fassbender. Connective Tissue Destruction in Rheumatoid Arthritis: Therapeutic Potential of Selective Metalloproteinase Inhibitors, B. Henderson and S. Blake. Lysosomal Cysteine Endopeptidases in the Degradation of Cartilage and Bone, D.J. Buttle. Glossary. Key to Illustrations. Index.
Contributors. Series Preface. Preface. Introduction. The Background to Autoimmunity, W.M. Williams, M.R. Ehrenstein, and D.A. Isenberg. Immunological Tolerance and its Implications for Autoimmunity, N.A. Mitchison. Peptide Blockade and Antigen-specific Modulation of Autoimmune Disease, D.C. Wraith. Monoclonal Antibody Therapy of Experimental Arthritis - Comparison with Cyclosparin A for Elucidating Cellular and Molecular Disease Mechanisms, M.E.J. Billingham. Anti-CD4 and Other Antibodies to Cell Surface Antigens for Therapy, F. Emmrich, H. Schulze-Koops, and G. Burmester. Are Imbalances in Cytokine Function of Importance in the Pathogenesis of Rheumatoid Arthritis?, M. Feldmann, F.M. Brennan, E.R. Abney, A. Hales, Y. Chernajovsky, P. Katsikis, A. Corcoran, C. Haworth, A. Cope, D. Gibbons, C.Q. Chu, M. Field, B. Deleuran, R.O. Williams, and R.N. Maini. Naturally Occuring Inhibitors of Cytokines, W.P. Arend and J.-M. Dayer. Soluble Immunopeptides in Inflammatory Arthritis, J.A. Symons and G.W. Duff . Inflammatory Reactions in Arthritis, H.-G. Fassbender. Connective Tissue Destruction in Rheumatoid Arthritis: Therapeutic Potential of Selective Metalloproteinase Inhibitors, B. Henderson and S. Blake. Lysosomal Cysteine Endopeptidases in the Degradation of Cartilage and Bone, D.J. Buttle. Glossary. Key to Illustrations. Index.
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