The pneumallergens involved in respiratory allergy are multiple. The sensitization profile to these allergens may vary with age. The objective of our study is to specify the impact of age on the epidemiological and allergenic characteristics of patients with respiratory allergy. Patients and methods: Retrospective study of patients consulting for respiratory allergy at Abderahmen Mami Hospital (Ariana, Tunisia) between 2011 and 2017. We studied the clinical and allergenic features of three groups of patients: G1: 100 patients (2-10 years old); G2: 88 patients (11-17 years old) and G3: 319 adults (>18 years old). Results: The mean age was 24 years (2-78). Familial atopy was statistically more common in G1 and G2. Sensitization to dust mites was similar between groups, whereas sensitization to pollens was significantly higher in G3. Monosensitization was statistically more frequent in G1 and G2. Conclusion: The frequency of pollinosis and polysensitization is more marked in adults than in children.