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The broad objective of this research is to evaluate the impact of capital structure on profitability of commercial banks in Nigeria, 2008-2017. The specific objectives are to: evaluate the impact of shareholders' fund on profitability of commercial banks in Nigeria, evaluate the impact of total asset on profitability of commercial banks in Nigeria. Investigate the impact of financial leverage on profitability of commercial banks in Nigeria. The study applied panel data models on annual data of the commercial banks within the scope. The study concluded that financial leverage and total assets were positively and significant in impacting profitability of commercial banks in Nigeria while shareholder fund was negative significant in impacting profitability of commercial banks in Nigeria. The study also recommended that commercial banks should imbibe trade off capital structure theory in financing its operations by either substituting gearing for shareholders' fund or shareholders' fund for gearing until an optimal and desired capital structure is arrived at.