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Intense activities in industrial and agricultural sectors have inevitably increased the levels of heavy metals in natural waters. Heavy metals play a major role among pollutants of environmental concern.Cadmium causes alteration in haematology and liver of .The Clarias batrachus toxicity of Cadmium is connected to the metal specification and water composition.This book focuses on the impact of heavy metal, cadmium on important food fish Clarias batrachus which is under the threat of this heavy metal.our results suggest that water pollution in capable of inducing morphological alteration in haematological parameters, histopathological organs , which may cause physiometabolic dysfunction in Clarias batrachus. A scientific method of detoxification is essential to improve the health of these economic fish,Clarias batrachus in any stressed environmental conditions. Laws enacted to protect environment should be enforced.