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The M-current (of the KCNQ2/3 channel) is voltage- gated potassium current that controls neuronal excitability. Mutations of the KCNQ2/KCNQ3 genes cause BFNC, a neonatal form of epilepsy. Despite substantial research, we do not understand yet the mechanisms by which M-channels modulate neuronal excitability. This book, therefore, evaluates the impact of these channels on the excitability of hippocampal neurons and transmitter release. It appraises the impact of M-channels on spontaneous excitatory/inhibitory post-synaptic currents (sEPSCs/sIPSCs), as well as miniature EPSCs/IPSCs. It also…mehr

Produktbeschreibung
The M-current (of the KCNQ2/3 channel) is voltage-
gated potassium current that controls neuronal
excitability. Mutations of the KCNQ2/KCNQ3 genes
cause BFNC, a neonatal form of epilepsy. Despite
substantial research, we do not understand yet the
mechanisms by which M-channels modulate neuronal
excitability. This book, therefore, evaluates the
impact of these channels on the excitability of
hippocampal neurons and transmitter release. It
appraises the impact of M-channels on spontaneous
excitatory/inhibitory post-synaptic currents
(sEPSCs/sIPSCs), as well as miniature EPSCs/IPSCs.
It also assesses the possible contribution of
somatic versus axonal/presynaptic M-channels to
transmitter release, and explores a possible
functional interaction between M-channels and SNARE
proteins such as syntaxin-1A. This book should
provide a basic understanding of the
pathophysiological processes of neuronal
hyperexcitability and also afford a therapeutic
potential for the treatment of major neurological
disorders like epilepsy, migraine or neuropathic
pain. The book is appointed to scientists and to any
person who is interested in this field.
Autorenporträt
Nurit Degani-Katzav, Ph.D.: Completed Ph.D. studies, and M.Sc.
studies with honors, in Life Sciences in Sackler School of
Medicine, Tel-Aviv University, Israel. Completed B.Sc. studies
in Life Sciences in the Hebrew University of Jerusalem, Israel.
Post-doctorate Fellow in Bar-Ilan University in the department
of Life Science, Israel.