This book explored system-wide effects of information technology on population health outcomes among sovereign countries of Africa. It will be a perfect read for a larger audience as it touches on several issues including health system strengthening, information science, global health, impact evaluation, and global policy and advocacy.This study represented in this book is a product of my doctoral research. This study used health analytics approach to evaluate the association between population health outcomes and Information and Communication Technology (ICT) infrastructure at a country level. This study used aggregate data obtained from the World Bank database, and the International Telecommunication Union (ITU) database for 53 African countries for the periods 2000 to 2016, and quantitatively explored the impact of ICT infrastructure diffusion on population health outcomes. ICT data was obtained from the ITU database. Similarly, population health attributes were obtained from the World Bank database. ICT infrastructure variables used in this study include: internet access, mobile phone use, and fixed telephone subscriptions.