Maxillofacial prostheses play a vital role in comprehensive rehabilitation by restoring physical and psychological well-being in patients with missing or disfigured anatomical structures due to congenital abnormalities, trauma, or disease It is possible to restore esthetics, function and re-establish the self confidence of the patient by providing a well designed prosthesis such as a prosthetic ear, eye, nose, cranial plate or a combination of these. Achieving adequate retention of the prosthesis, especially when the defect is extensive, is a big challenge and requires a multi-disciplinary approach. This book discusses the role of implants in comprehensive maxillofacial rehabilitation.