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The present study aimed to evaluate implication of aluminum in exerting male reproductive and thyroid hormonal disorders, and lipid profile changes among aluminum workers. Cross-sectional study was carried on 56 male aluminum workers in aluminum welding factory. Aluminum dust level was measured and questionnaire was conducted for all participants. Urinary aluminum level, serum total cholesterol, triglycerides, high density lipoprotein, high sensitive c-reactive protein, apolipoprotein- E, total antioxidant capacity, malondialdehyde, luteinizing hormone, follicle stimulating hormone, testosterone,17-beta-estradiol, free triiodothyronine, free thyroxin and thyroid stimulating hormone were measured in both groups. Aluminum dust mean concentration was 1.6 ± 0.3 mg/m3 in the present study. Urinary aluminum, serum triglycerides, very low density lipoprotein cholesterol, high sensitive C-reactive protein and malondialdehyde levels were significantly higher while total antioxidant capacity was significantly lower among the exposed workers compared to controls.