Rehabilitation goals are focused on the restorative, supportive, palliative and preventive aspects of treatment. Advanced cancers or trauma destroying structures, which may include soft and hard tissues of jaws, facial skeleton, oral tissues, lips, checks, nose and eyes, can affect the maxillofacial region. The defect may result in oroantral, oronasal, oronasal-orbital communication. The primary objective of rehabilitation is to preserve and restore the function of speech and swallow, preludes to the image restoration and boosts confidence of the patients so they can return to society; who have suffered the ravages of disfigurement. As we all know, every human being has the right to look like a normal human being, whatever the circumstances. In this book, I have tried to solve the challanges faced by the maxillofacial prosthodontist while making an impact on the prosthesis.Rehabilitation of such patients is quiet challenging and requires multidisciplinary team for comprehensive care and optimal post treatment functional outcomes.