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This book contains the improved system that assists the physician to evaluate Acute Lymphocytic Leukemia. We proposed Acute Lymphocytic Leukemia detection and classification (ALLDC) system for detecting and classifying ALL cells in ALL-IDB1 image datasets. To achieve this aim, our proposed ALLDC system classifies all cells as ALL and noncancerous cells using two classification techniques applied separately to classify the WBCs normal or blast cells: two classifiers are suggested in our work such as k-nearest neighbour (KNN) and Artificial Neural Networks (ANN).