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Main description:
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
Table of contents:
In Vitro Neurotoxicology: Introduction to Concepts. Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment. Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics. In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis. Role of Apoptosis in Neurotoxicology. Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia. Cell-Type-Specific Responses of the Nervous System to Lead. Effects of Toxicants on Neural Differentiation. Impairment of Synaptic Function by Exposure to Lead. Aggregating Brain Cell Cultures for Neurotoxicological Studies. Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors. Establishing In Vitro Models to Study Endogenous Neurotoxicants. Appendix: Annotated Reading List. Index.
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
Table of contents:
In Vitro Neurotoxicology: Introduction to Concepts. Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment. Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics. In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis. Role of Apoptosis in Neurotoxicology. Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia. Cell-Type-Specific Responses of the Nervous System to Lead. Effects of Toxicants on Neural Differentiation. Impairment of Synaptic Function by Exposure to Lead. Aggregating Brain Cell Cultures for Neurotoxicological Studies. Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors. Establishing In Vitro Models to Study Endogenous Neurotoxicants. Appendix: Annotated Reading List. Index.
"This book covers a wide range of topics, starting with a nice overview of the field of neurotoxicology. Moving on to the meat of the material, the effects of toxins on neural development, function, and degeneration are examined, using well studied neurotoxicants as examples. A thorough list of articles as well as an annotated reading list are valuable additions, making the book an excellent reference. This is a valuable reference for anyone studying the advances in neurotoxicology. It is concise and easy to comprehend, without sacrificing quality in the process. It is written by leaders in the field, ensuring the information is relevant and up-to-date."-Doody's Health Sciences Book Review Journal
"This is a useful book that updates new an improved in vitro methods to help further understanding neurotoxicology. The information presented is exciting, the methods proposed are often innovative, and readers will find a challenging glimpse into the future contributions their own research efforts can generate. Neurotoxicologists will find studying this volume rewarding and inspiring." - Vet Human Toxicol
"...a helpful and up to date book..." - BTS Newsletter
"This is a useful book that updates new an improved in vitro methods to help further understanding neurotoxicology. The information presented is exciting, the methods proposed are often innovative, and readers will find a challenging glimpse into the future contributions their own research efforts can generate. Neurotoxicologists will find studying this volume rewarding and inspiring." - Vet Human Toxicol
"...a helpful and up to date book..." - BTS Newsletter