Robert L Bronaugh, Howard I Maibach

In Vitro Percutaneous Absorption

Principles, Fundamentals, and Applications

• Gebundenes Buch

Produktbeschreibung

This book addresses in vitro percutaneous absorption issues. It also considers many more variables in an in vitro experiment including: diffusion cell design, receptor fluid, preparation of skin, and temperature. The book is useful for both new and experienced investigators to design experiments.

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Produktdetails

• Verlag: CRC Press / Taylor & Francis Ltd (Sales)
• Seitenzahl: 288
• Erscheinungstermin: 24. Juli 1991
• Englisch
• Abmessung: 262mm x 185mm x 22mm
• Gewicht: 744g
• ISBN-13: 9780849347481
• ISBN-10: 0849347483
• Artikelnr.: 21453776

Autorenporträt

Bronaugh\, Robert L.; Maibach\, Howard I.

Inhaltsangabe

1. Preparation of Human and Animal Skin 2. Diffusion Cell Design 3. A
Flow-Through Diffusion Cell 4. Individual and Regional Variation with In
Vitro Percutaneous Absorption 5. Receptor Fluids 6. Assessment of Vehicle
Factors Influencing Percutaneous Absorption 7. Cutaneous Metabolism 8.
Effect of Occlusion 9. Skin Storage Conditions 10. In Vitro Absorption
through Damaged Skin 11. Localization of Drugs in the Skin 12. Expression
of Absorption Data 13. The LPP Theory of Skin Penetration Enhancement 14.
In Vitro Percutaneous Absorption of Alachlor and Atrazine 15. In Vivo - In
Vitro Correlations for Hydrophobic Compounds 16. In Vitro Absorption: Skin
Flap Model 17. Percutaneous Penetration from Soil: Inhibition or
Enhancement? 18. Short-Term In Vitro Skin Exposure 19. Protocol for In
Vitro Percutaneous Absorption Studies 20. Finite Dose In Vitro Percutaneous
Permeation Based on the Diffusion Model: Estimation of Pharmacokinetic
Parameters and Prediction of the Pharmacokinetic Profiles 21. Effect of
Sodium Lauryl Sulfate-Induced Skin Irritation on In Vitro Percutaneous
Absorption