Herbal medicines are used by about 80 % of world population, mainly in the developing countries, for primary health care, due to its better cultural acceptability, better compatibility with the human body, safety and lesser side effects. WHO has defined traditional medicines as practiced that for hundreds of years before the development of the modern system of medicine and are still in use. However, in the last few years there has been a major increase in their use in the developing countries have a well founded traditional system of medicines, where plant based therapeutic agents occupy an important role in health care products. Plants have been used for the treatment of different kind of diseases from more than 3000 years. The biologically active natural compounds may have anticholinesterase activity and can be used as leader compounds for the synthesis of new drugs. The bioactive substances from fruits, vegetables and medicinal plants mainly includes indole, steroidal-piperidine-alkaloids, furanocoumarins, xanthones, flavonoids and diterpenes derivatives play a major role in the slowing of many pathogenesis and neurodegenerative disorders such as Alzheimer's disease.