Indomethacin Pulsatile Drug Delivery - Yarguntla, Srinivasa Rao
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Six formulations of modified pulsincap of Indomethacin were developed by using various grades and ratios by using Hydroxy propyl methyl cellulose K-100M, CCS as rate controlling polymers. Magnesium sterate and talc are the other components used. Blends were evaluated for various parameters such as bulk density, tapped density,angle of repose, Hausners ratio, Carr's index. Capsules were evaluated for their physical appearance,drug content, % weight variation and Invitro drug release. All the physico chemical properties are with in the acceptable limits. Based on the results, formulation F6…mehr

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Produktbeschreibung
Six formulations of modified pulsincap of Indomethacin were developed by using various grades and ratios by using Hydroxy propyl methyl cellulose K-100M, CCS as rate controlling polymers. Magnesium sterate and talc are the other components used. Blends were evaluated for various parameters such as bulk density, tapped density,angle of repose, Hausners ratio, Carr's index. Capsules were evaluated for their physical appearance,drug content, % weight variation and Invitro drug release. All the physico chemical properties are with in the acceptable limits. Based on the results, formulation F6 containing HPMC-K100M in the concentration double the drug's concentration was identified as an ideal and better formulation among all formulations. In-vitro release of an optimized formulation of Indomethacin (f6) was found to be 96.05% in 4hrs. Based on the regression coefficient (R2 ) values of various plots, the optimized formulation was found to follow First-order release model and mechanism of drug release was non-fickian type of diffusion based on 'n' value of Korsemeyer-Peppas model.
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Autorenporträt
Dr. Y.  Srinivasa Rao completed B. Pharm, M. Pharm and PhD from A.U. and PDF in KPU, Japan. He received the Best Research Paper Award 4 times by Andhra University.  He received the "YOUNG SCIENTIST AWARD-2016" by CEGR, New Delhi. His write-ups near about 150 Research Paper Publications in National and International journals.