Dental infection control and occupational safety are very important aspect of dentistry. It is essential to provide safe care to patient and at the same time not to be affected personally by occupational hazards. While patient safety addresses control of disease transmission to patient during care, occupational safety addresses control of occupational hazards to care provider.Dentist must follow effective infection control procedure in their practice. A positive step by step approach should be employed.This literature is to provide a background about the possible ways of transmission of infection, spreading, and procedures recommended for preventing their spread in the discipline of prosthodontics.