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This issue of Physician Assistant Clinics, guest edited by Robert Paxton, PA-C, MPAS, is devoted to Infectious Disease. Articles in this issue include: Community Acquired Pneumonia; Skin and Soft Tissue Infections; Meningitis +/- Encephalitis; Genitourinary Infections; Sexually Transmitted Infections; Human Immunodeficiency Virus; Tuberculosis; Infectious Diarrhea; Tick-borne Disease; Orthopedic Infections; Bite-related Infections; Hepatitis C Virus; Epstein-Barr Virus and Cytomegalovirus Infections; and Endemic Fungal Infections in the U.S.