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Numerous Gulf War veterans have reported a range of illnesses and symptoms after serving in the Persian Gulf. Some of the reported symptoms are similar to those caused by diseases known to be prevalent in that region. This report discusses these infectious diseases and considers them as potential causes of the symptoms reported by the veterans. The authors present a short summary of etiology, diagnosis, and treatment for several infectious diseases and infectious organisms, including bacterial, viral, and parasitic infections. Two biological agents--anthrax and botulinum toxin--are also discussed.