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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Infiltration is the diffusion or accumulation (in a tissue or cells) of substances not normal to it or in amounts in excess of the normal. The material collected in those tissues or cells is called infiltrate. As part of a disease process, infiltration is sometimes used to define the invasion of cancer cells into the underlying matrix or the blood vessels. Similarly the term may describe the deposition of amyloid protein. During leukocyte extravasation white blood cells move in response to cytokine chemicals (chemotaxis), from within the blood out to infiltrate into the diseased or infected tissues.