Epidemiological studies of Chronic Bronchitis/ Chronic Obstructive Airway Disease (CB/COAD) have demonstrated that hypersecretory glandular activity, as weIl as infections, are not the most important risk factors determining the serious decline in lung function in this disease. Instead, inflammatory indices are emerging as characteristic features of the pathology and pathophysiology of CB/COAD. It is possible that continuous inflammatory processes cause structural changes and thus provide the anatomical basis for airway obstruction which, once estab lished, is only partly reversible. We feIt…mehr
Epidemiological studies of Chronic Bronchitis/ Chronic Obstructive Airway Disease (CB/COAD) have demonstrated that hypersecretory glandular activity, as weIl as infections, are not the most important risk factors determining the serious decline in lung function in this disease. Instead, inflammatory indices are emerging as characteristic features of the pathology and pathophysiology of CB/COAD. It is possible that continuous inflammatory processes cause structural changes and thus provide the anatomical basis for airway obstruction which, once estab lished, is only partly reversible. We feIt it was timely to gather leading international researchers who could provide critical updates on CB/COAD, its pathology and clinical/ experimental assessments. The latter aspect included not only the fundamentals of airway function but also, and in greater detail, cellular and solute indices which can now be used to determine inflammation in CB/COAD. The meeting was made possible by a grant from Draco/Astra (Sweden and Finland). We particularly acknowledge the expert assistance of Mrs. Eva Engberg in all facets of the present work.
Airway Pathology of Functional Significance in Chronic Bronchitis and Chronic Obstructive Airway Disease.- 1) Airway Pathology of Functional Significance in Chronic Bronchitis and Chronic Obstructive Airway Disease.- Assessment of Long-Term Changes in Airway Function.- 2) Assessment of Long-Term Changes in Airway Function.- The Role of Measurements of Airway Responsiveness.- 3) The Role of Measurements of Airway Responsiveness.- Effects of Corticosteroids in "Chronic Bronchitis" and "Chronic Obstructive Airway Disease".- 4) Effects of Corticosteroids in "Chronic Bronchitis" and "Chronic Obstructive Airway Disease".- Epidemiology of Obstruction, Exacerbations and Hyper-Reactivity. Effects of Glucocorticosteroids and other Antiinflammatory Treatment.- 5) Epidemiology of Obstruction, Exacerbations and Hyper-Reactivity. Effects of Glucocorticosteroids and other Anti- Inflammatory Treatment.- Airways Hyperreactivity, Bronchial Inflammation and Obstructive Lung Disease.- 6) Airways Hyperreactivity, Bronchial Inflammation and Obstructive Lung Disease.- Clinical Trials in Asthma and Chronic Airflow Obstruction.- 7) Clinical Trials in Asthma and Chronic Airflow Obstruction.- A Critical Look at Blood Samples in CB and COAD.- 8) A Critical Look at Blood Samples in CB and COAD.- Seasonal Variation in The Phagocytic Activity and Arachidonic-Acid Metabolism of Human Blood Monocytes in Healthy Non-Smokers, Smokers and Chronic Bronchitics.- 9) Seasonal Variation in The Phagocytic Activity and Arachidonic-Acid Metabolism of Human Blood Monocytes in Healthy Non-Smokers, Smokers and Chronic Bronchitics.- A Critical View on Lavage Sampling Techniques.- 10) A Critical View on Lavage Sampling Techniques.- Assessment of Soluble Parameters in Sputum.- 11) Assessment of SolubleParameters in Sputum.- Sputum Cell Counts in Airway Disease: a Useful Sampling Technique.- 12) Sputum Cell Counts in Airway Disease: a Useful Sampling Technique.- Bronchial Biopsies in Drug Intervention Studies in CB and COAD.- 13) Bronchial Biopsies in Drug Intervention Studies in CB and COAD.- Inflammatory Indices for Chronic Bronchitis and Chronic Obstructive Airway Disease. Cell Populations in Bronchial and Bronchoalveolar Lavage.- 14) Inflammatory Indices for Chronic Bronchitis and Chronic Obstructive Airway Disease. Cell Populations in Bronchial and Bronchoalveolar Lavage.- The Generation of Reactive Oxygen-Derived Species by Phagocytes.- 15) The Generation of Reactive Oxygen-Derived Species by Phagocytes.- Inflammatory Indices in Chronic Bronchitis. Monocyte-Macrophage Microbicidal Activity.- 16) Inflammatory Indices in Chronic Bronchitis. Monocyte-Macrophage Microbicidal Activity.- Indices of Inflammatory Activity in CB and COAD. Phagocyte Secretion and Chemotaxis.- 17) Indices of Inflammatory Activity in CB and COAD. Phagocyte Secretion and Chemotaxis.- Inflammatory Indices for Chronic Bronchitis and COAD Proteases and Antiproteases.- 18) Inflammatory Indices for Chronic Bronchitis and COAD Proteases and Antiproteases.- Exudative Indices in Airways Inflammation.- 19) Exudative Indices in Airways Inflammation.- The Measuring of "Respiratory-Membrane Permeability" and Local Production of Immunoglobulins and Antibodies by Means of an Analysis of Sputum.- 20) The Measuring of "Respiratory-Membrane Permeability" and Local Production of Immunoglobulins and Antibodies by Means of an Analysis of Sputum.- A Critical Look at Mucus Markers.- 21) A Critical Look at Mucus Markers.- Points of Importance in Long Term Intervention Studies in CB/COAD.- 22) Points ofImportance in Long Term Intervention Studies in CB/COAD.- Which Markers of Inflammation Should be Used in Therapeutic Intervention Studies of CB/COAD?.- 23) Which Markers of Inflammation Should be Used in Therapeutic Intervention Studies of CB/COAD?.
Airway Pathology of Functional Significance in Chronic Bronchitis and Chronic Obstructive Airway Disease.- 1) Airway Pathology of Functional Significance in Chronic Bronchitis and Chronic Obstructive Airway Disease.- Assessment of Long-Term Changes in Airway Function.- 2) Assessment of Long-Term Changes in Airway Function.- The Role of Measurements of Airway Responsiveness.- 3) The Role of Measurements of Airway Responsiveness.- Effects of Corticosteroids in "Chronic Bronchitis" and "Chronic Obstructive Airway Disease".- 4) Effects of Corticosteroids in "Chronic Bronchitis" and "Chronic Obstructive Airway Disease".- Epidemiology of Obstruction, Exacerbations and Hyper-Reactivity. Effects of Glucocorticosteroids and other Antiinflammatory Treatment.- 5) Epidemiology of Obstruction, Exacerbations and Hyper-Reactivity. Effects of Glucocorticosteroids and other Anti- Inflammatory Treatment.- Airways Hyperreactivity, Bronchial Inflammation and Obstructive Lung Disease.- 6) Airways Hyperreactivity, Bronchial Inflammation and Obstructive Lung Disease.- Clinical Trials in Asthma and Chronic Airflow Obstruction.- 7) Clinical Trials in Asthma and Chronic Airflow Obstruction.- A Critical Look at Blood Samples in CB and COAD.- 8) A Critical Look at Blood Samples in CB and COAD.- Seasonal Variation in The Phagocytic Activity and Arachidonic-Acid Metabolism of Human Blood Monocytes in Healthy Non-Smokers, Smokers and Chronic Bronchitics.- 9) Seasonal Variation in The Phagocytic Activity and Arachidonic-Acid Metabolism of Human Blood Monocytes in Healthy Non-Smokers, Smokers and Chronic Bronchitics.- A Critical View on Lavage Sampling Techniques.- 10) A Critical View on Lavage Sampling Techniques.- Assessment of Soluble Parameters in Sputum.- 11) Assessment of SolubleParameters in Sputum.- Sputum Cell Counts in Airway Disease: a Useful Sampling Technique.- 12) Sputum Cell Counts in Airway Disease: a Useful Sampling Technique.- Bronchial Biopsies in Drug Intervention Studies in CB and COAD.- 13) Bronchial Biopsies in Drug Intervention Studies in CB and COAD.- Inflammatory Indices for Chronic Bronchitis and Chronic Obstructive Airway Disease. Cell Populations in Bronchial and Bronchoalveolar Lavage.- 14) Inflammatory Indices for Chronic Bronchitis and Chronic Obstructive Airway Disease. Cell Populations in Bronchial and Bronchoalveolar Lavage.- The Generation of Reactive Oxygen-Derived Species by Phagocytes.- 15) The Generation of Reactive Oxygen-Derived Species by Phagocytes.- Inflammatory Indices in Chronic Bronchitis. Monocyte-Macrophage Microbicidal Activity.- 16) Inflammatory Indices in Chronic Bronchitis. Monocyte-Macrophage Microbicidal Activity.- Indices of Inflammatory Activity in CB and COAD. Phagocyte Secretion and Chemotaxis.- 17) Indices of Inflammatory Activity in CB and COAD. Phagocyte Secretion and Chemotaxis.- Inflammatory Indices for Chronic Bronchitis and COAD Proteases and Antiproteases.- 18) Inflammatory Indices for Chronic Bronchitis and COAD Proteases and Antiproteases.- Exudative Indices in Airways Inflammation.- 19) Exudative Indices in Airways Inflammation.- The Measuring of "Respiratory-Membrane Permeability" and Local Production of Immunoglobulins and Antibodies by Means of an Analysis of Sputum.- 20) The Measuring of "Respiratory-Membrane Permeability" and Local Production of Immunoglobulins and Antibodies by Means of an Analysis of Sputum.- A Critical Look at Mucus Markers.- 21) A Critical Look at Mucus Markers.- Points of Importance in Long Term Intervention Studies in CB/COAD.- 22) Points ofImportance in Long Term Intervention Studies in CB/COAD.- Which Markers of Inflammation Should be Used in Therapeutic Intervention Studies of CB/COAD?.- 23) Which Markers of Inflammation Should be Used in Therapeutic Intervention Studies of CB/COAD?.
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