L. Gordon Letts / Douglas W. Morgan

Inflammatory Processes:

Molecular Mechanisms and Therapeutic Opportunities
Herausgegeben:Letts, L. Gordon; Morgan, Douglas W.

• Gebundenes Buch

Produktbeschreibung

In November 1998 many of the key leaders of new drug discovery for
inflammatory diseases gathered at Hershey, Pennsylvania for the 9th
International Conference of the Inflammation Research Association. The
Conference was held over a five day period and provided a stimulating
environment for the open exchange of important advances in basic
inflammation research as well as new drug discovery and development.
This book encompasses some of the highlights of several presentations
made at the Conference. It contains some of the latest and important
developments in the field of inflammation research.
Topics include the status of eotaxin and chemokines in asthma and
allergy, signal transduction and regulation of diverse mediators such as
the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as
regulators of AP-1, macrophage metalloproteinases, lymphotoxin and
further insights into the role of MCP-1 in disease. Also discussed are
drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Produktdetails

• Progress in Inflammation Research
• Verlag: Springer, Basel / Springer, Berlin
• 2000.
• Seitenzahl: 144
• Englisch
• Abmessung: 238mm x 171mm x 13mm
• Gewicht: 356g
• ISBN-13: 9783764360252
• ISBN-10: 3764360259
• Artikelnr.: 27452997

Inhaltsangabe

Contents. List of Contributors. Preface. T.J. Mitchell and T.J.
Williams: The role of eotaxin and related CC-chemokines in asthma and
allergy. Roger J. Davis: Signal transduction by the JNK group of MAP
kinases. Marie Chabot-Fletcher: TNF and IL-1 signaling to NF-kB. Anthony
M. Manning: Small molecule regulators of AP-1 and NF-kB. Robert T.
Abraham: Mammalian target of rapamycin: Immunosuppressive drugs offer
new insights into cell growth regulation. Catherine A. Burton, John
Boylan, Candy Robinson, Janet Kerr and Pamela Benfield: Constitutive
expression of a tumor suppressor leads to tumor regression in a
xenograft model. Steven D. Shapiro: Macrophage metalloproteinases in
destructive inflammatory diseases. Nancy H. Ruddle: Lymphotoxin in
inflammation and lymphoid organ development: Variations on a theme.
Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam and
Stephen W. Chensue: Chemokine/cytokine biology during the evolution of
fibrotic disease. Long Gu, Susan C. Tseng and Barrett J. Rollins: The
role of MCP-1 in disease. Lisa A. Beck, Cristiana Stellato, Syed
Shahabuddin, Renate Nickel and Robert P. Schleimer: The role of
chemokines in allergic diseases of the airways. James Winkler and Ken
Tramposch (coordicators): Ninth International Conference of the
Inflammation Research Association, November 1-5, 1998: Summaries of
workshops and poster discussions. William Williams and Elizabeth Arner
(chair persons): Targets in rheumatoid and osteoarthritis. Lawrence
Wennogle and Nancy Cusack (chair persons): Signal transduction and
regulation of gene expression. James Burke and Floyd Chilton (chair
persons): Mediators in inflammation and their enzymes. Denis Schrier and
Fandrew Issekutz (chair persons): Cell adhesion molecules and leukocyte
trafficking. Robert M. Strieter and David Underwood (chair persons):
Pulmonary inflammation, fibrosis, and disease. W. Hunter and E. Turley
(chair persons): Angiogenesis, wound repair and skin inflammation.
Index.