Marta Ugarte

Influence of zinc on the normal and ischaemic retina

In vitro and in vivo studies

• Broschiertes Buch

Produktbeschreibung

In the mammalian retina, endogenous chelatable zinc
was shown to be localised mainly in the
photoreceptors and retinal pigment epithelium. Zinc
localisation in the photoreceptors varied in light
and dark. Low (100 micromolar) levels of zinc
sulphate (ZnSO4) counteracted glutamate- and
NMDA-induced lactate dehydrogenase release in rat
cortical cultures; as well as the changes in
Gamma-aminobutyric acid (GABA)-immunoreactivity
mediated by experimental ischaemia and NMDA in
isolated rabbit retinas. However, high (500
micromolar) levels of ZnSO4 caused lactate
dehydrogenase release and alterations in
GABA-immunoreactivity, and exacerbated the effects of
NMDA or ischaemia to the retina. When very low (1
micromolar) concentrations of ZnSO4 were present
during ischaemia, GABA-immunoreactivity was localised
to Müller cells, indicating that zinc prevents the
metabolism of GABA in Müller cells in the ischaemic
retina. High (500 micromolar) concentrations of ZnSO4
potentiated reactive oxygen species formation while
ameliorating lipid peroxidation. When low (1 nanomol)
levels of ZnSO4 were injected into the vitreous
humour of the rabbit eye the retina remained unaffected.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 188
• Englisch
• Abmessung: 220mm
• ISBN-13: 9783639168693
• ISBN-10: 3639168690
• Artikelnr.: 26614507

Autorenporträt

Marta Ugarte, DPhil MRCOphth: Studied Medicine at the University
of the Basque Country (Spain), did her DPhil at the University of
Oxford (UK) and trained in clinical ophthalmology in London and
Manchester. NIHR clinical lecturer in ophthalmology at the
University of Manchester (UK).