Inherited Bleeding Disorders in Women

Herausgegeben:Kadir, Rezan A.; James, Paula D.; Lee, Christine A.

• Gebundenes Buch

Produktbeschreibung

The essential guide for understanding and treating women with inherited bleeding disorders, revised and updated

Now in its second edition, Inherited Bleeding Disorders in Women includes the most recent developments and research in the field. This important guide offers the most current information available for the effective management of these complex and difficult to diagnose disorders. Treating women with inherited bleeding disorders can be challenging and requires close collaboration among practitioners in different specialties.

This important guide is written by a team of international experts who offer advice and practical suggestions for treating women with inherited bleeding disorders. Inherited Bleeding Disorders in Women comprehensively covers obstetric and gynecological issues for carriers of hemophilia, women with von Willebrand disease, rare bleeding disorders and inherited platelet disorders. This important resource:
_ Offers an updated guide for hematologists, obstetricans and gynecologists and other clinicians treating women with inherited bleeding disorders
_ Includes information for treating both common and rare bleeding disorders
_ Contains the most recent developments and advances in the field for the treatment and management of inherited bleeding disorders in women
_ Presents information from noted experts in the field
_ Offers a multidisciplinary approach to the topic

Written for hematologists, obstetricians and gynecologists and other clinicians working with women, Inherited Bleeding Disorders in Women has been fully revised and updated and continues to serve as a trusted guide for the management and treatment of women with inherited bleeding disorders.

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Produktdetails

• Verlag: Wiley & Sons / Wiley-Blackwell
• Artikelnr. des Verlages: 1W119426020
• 2. Aufl.
• Seitenzahl: 264
• Erscheinungstermin: 29. Januar 2019
• Englisch
• Abmessung: 257mm x 175mm x 18mm
• Gewicht: 612g
• ISBN-13: 9781119426028
• ISBN-10: 1119426022
• Artikelnr.: 53022122

Autorenporträt

Rezan A. Kadir, Professor in the Department of Obstetrics and Gynaecology and Katharine Dormandy Haemophilia and Thrombosis Centre, The Royal Free Foundation Hospital and Institute for Women's Health, University College London, London, UK. Paula D. James, Professor in the Department of Medicine, Queen's University, Kingston, Canada. Christine A. Lee, Emeritus Professor of Hemophilia, University College London, London, UK.

Inhaltsangabe

Preface to Second Edition ix

Preface to First Edition xi

List of Contributors xiii

1 Hematological Assessment of a Patient with an Inherited Bleeding Disorder 1
Sue Pavord and Henna Wong

1.1 Introduction 1

1.2 Normal Hemostasis 1

1.3 Defects of Hemostasis 5

1.4 Clinical Presentation of Bleeding 5

1.5 Diagnosis 6

1.6 Approach to a Female with a Bleeding History 6

1.7 Summary 10

References 11

2 Bleeding Assessment Tools 13
Sarah H. O'Brien and Paula D. James

2.1 Introduction 13

2.2 Evolution of Vicenza-Based Bleeding Assessment Tools 13

2.3 Women's Studies Using Vincenza-Based Bleeding Tools 22

2.4 Tools to Evaluate Menstrual Blood Loss 23

2.5 Young Women's Hematology and Bleeding Assessment Tools 25

2.6 Clinical Utility of Bleeding Assessment Tools 25

2.7 Conclusion 26

References 27

3 Physiology of Menstruation 29
Jane J. Reavey, Jacqueline A. Maybin, and Hilary O.D. Critchley

3.1 Introduction 29

3.2 Normal Menstruation 29

3.3 Neuroendocrine Hormones 30

3.4 Menarche 31

3.5 Ovarian Follicle Development and Endocrine Function 31

3.6 Endometrium 33

3.7 Secretory Phase 34

3.8 Menstruation 35

3.9 Control of Bleeding 37

3.10 Endometrial Repair 38

3.11 Proliferative Phase 40

3.12 Summary 40

References 41

4 Gynecology 45
Joanna S. Davies and Rezan A. Kadir

4.1 Introduction 45

4.2 Heavy Menstrual Bleeding 48

4.3 Management of Acute Episodes of Heavy Menstrual Bleeding 58

4.4 Ovulation Bleeding 59

4.5 Endometriosis 59

4.6 Other Gynecological Conditions 60

4.7 Conclusion 61

References 61

5 Carriers of Hemophilia A and Hemophilia B 65
Roseline d'Oiron

5.1 Inheritance 65

5.2 Screening for the Genetic Status of Carriers of Hemophilia 65

5.3 Confusion Between Genetic and Coagulation Testing 66

5.4 When to Perform Genetic Testing 67

5.5 What Reasons might Contribute to Delayed Genetic Diagnosis of Carriership? 68

5.6 Bleeding Disorders in Carriers of Hemophilia 68

5.7 Quality of Life of Carriers of Hemophilia 73

5.8 Carriers of Hemophilia A and B and Pregnancy 73

5.9 How to Improve Care for Carriers of Hemophilia 77

References 79

6 Von Willebrand Disease 83
Carolyn M. Millar

6.1 Introduction 83

6.2 Structure and Function of Von Willebrand Factor 83

6.3 Von Willebrand Factor Levels and Prevalence of Von Willebrand Disease 84

6.4 VWF Levels, the Menstrual Cycle and Pregnancy 84

6.5 Von Willebrand Disease Classification and Inheritance 85

6.6 Clinical Presentation 87

6.7 Menorrhagia and Postpartum Hemorrhage 87

6.8 Diagnosis and Laboratory Testing 88

6.9 Management of Von Willebrand Disease 90

6.10 Management of Gynecological Bleeding 91

6.11 Obstetric Management of Von Willebrand Disease 92

6.12 Neonatal Management 94

6.13 Cases 94

References 96

7 Factor XI Deficiency 101
Bethan Myers and Rezan A. Kadir

7.1 Factor XI Structure and Function in Coagulation 101

7.2 Incidence and Inheritance of Factor XI Deficiency 101

7.3 Bleeding Manifestations and Diagnosis of Factor XI Deficiency 103

7.4 Factor XI Deficiency and Gynecological Issues 103

7.5 Factor XI Deficiency and Pre