Innovation of benzimidazole metal chelates as pharmaceutical agents - Abu-Dief Mohammed, Ahmed Mohammed;El-Dabea, Tarek;El-Khatib, Rafat M.
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Metals and Ligands in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for several different applications, the design of new drugs and the relationship between structure and…mehr

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Produktbeschreibung
Metals and Ligands in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for several different applications, the design of new drugs and the relationship between structure and function. Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. The use of metals and their salts for medicinal purposes has been present throughout history. The interactions of transition metal complexes with DNA have been a subject of passionate research in the field of bioinorganic chemistry, ever since the discovery of cis-platin as an anticancer agent. It has been demonstrated that free radicals can damage DNA of bio-tissues, leading to increased rates of cancer.
Autorenporträt
Prof. Dr. Ahmed Mohammed Abu-Dief, Professor at Taibah University, Saudi Arabia. He published more than 160 articles in international journals, 15 books and participates in more than 125 workshops and international conferences with h-index 59. Moreover, he works as reviewer in 265 international journals and member of editorial board in 56 journals.